SCHEMBL31268752

SCHEMBL31268752

CC1(Oc2ncnc3c2nc(-c2cccc(OCCCOCC(=O)O)c2Cl)n3Cc2cc(Cl)ccc2C#N)CC1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 1/20 0.32
▸ EIF4EBP1 Q13541 17/20 0.32
▸ CNR1 P21554 1/20 0.32
▸ PTGDR2 Q9Y5Y4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31268802 0.92 EIF4EBP1 (0.33) PIK3CDEIF4EBP1CNR1
SCHEMBL31269249 0.90 PDCD1 (0.34) PIK3CDCNR1PTGDR2
SCHEMBL30983499 0.89 EIF4EBP1 (0.33) PIK3CDEIF4EBP1CNR1
SCHEMBL30983574 0.89 EIF4EBP1 (0.33) PIK3CDEIF4EBP1CNR1
SCHEMBL31268913 0.88 CNR1 (0.34) PIK3CDCNR1
SCHEMBL31269134 0.87 PLA2G2A (0.35) PIK3CDCNR1PTGDR2
SCHEMBL31269437 0.87 PPARD (0.32) PIK3CDEIF4EBP1CNR1
SCHEMBL31269222 0.87 CD274 (0.35) PIK3CDCNR1PTGDR2
SCHEMBL31269163 0.86 PLA2G2A (0.35) PIK3CDCNR1PTGDR2
SCHEMBL31269118 0.86 ACSL1 (0.36) PIK3CDEIF4EBP1CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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