SCHEMBL31269249

SCHEMBL31269249

COc1ccc(Cl)cc1Cn1c(-c2cccc(OCCCOCC(=O)O)c2Cl)nc2c(OC3(C)CC3)ncnc21

nearest known ligand 0.34

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ PDCD1 Q15116 4/20 0.34
▸ CD274 Q9NZQ7 4/20 0.34
▸ PIK3CD O00329 2/20 0.33
▸ PPARG P37231 1/20 0.32
▸ PPARD Q03181 1/20 0.32
▸ PTGDR2 Q9Y5Y4 3/20 0.32
▸ PTGER1 P34995 4/20 0.31
▸ ANO1 Q5XXA6 2/20 0.31
▸ CNR1 P21554 1/20 0.31
▸ ANO2 Q9NQ90 1/20 0.31
▸ CPT1A P50416 1/20 0.31
▸ CPT1B Q92523 1/20 0.31
▸ ADORA3 P0DMS8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31269222 0.97 CD274 (0.35) PDCD1CD274PIK3CDPTGDR2PTGER1
SCHEMBL31269043 0.95 PIK3CD (0.35) PDCD1CD274PIK3CDPTGER1CNR1
SCHEMBL31269105 0.95 PIK3CD (0.33) PDCD1CD274PIK3CDPPARDPTGDR2
SCHEMBL30983441 0.92 PDCD1 (0.36) PDCD1CD274PIK3CDPTGDR2PTGER1
SCHEMBL31268752 0.90 PIK3CD (0.32) PIK3CDPTGDR2CNR1
SCHEMBL30984001 0.90 ADORA3 (0.35) PDCD1CD274PIK3CDCNR1ADORA3
SCHEMBL31269188 0.90 CD274 (0.34) PDCD1CD274PIK3CDANO1CNR1
SCHEMBL31268913 0.89 CNR1 (0.34) PDCD1CD274PIK3CDPPARDPTGER1
SCHEMBL31269134 0.89 PLA2G2A (0.35) PIK3CDPPARGPPARDPTGDR2CNR1
SCHEMBL31268870 0.88 PDCD1 (0.34) PDCD1CD274PIK3CDPTGER1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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