SCHEMBL31268787

SCHEMBL31268787

Cc1ccnc(Cn2c(-c3ccc(N4CCNC(=O)CC4)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KCNH2 Q12809 2/20 0.33
▸ SCN5A Q14524 1/20 0.33
▸ SCN9A Q15858 1/20 0.33
▸ PIK3CD O00329 2/20 0.32
▸ CNR1 P21554 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31269156 0.94 NTRK1 (0.33) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL31269090 0.91 HTR6 (0.35) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL31269320 0.89 HTR6 (0.34) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL31269289 0.88 PIK3CD (0.34) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL31269124 0.88 CNR1 (0.33) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL31268791 0.87 CNR1 (0.39) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL31269236 0.86 PIK3CD (0.34) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL31268880 0.85 PIK3CD (0.32) KCNH2SCN5ASCN9APIK3CD
SCHEMBL31268976 0.85 PAK1 (0.39) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL31269036 0.84 SLC6A2 (0.34) KCNH2SCN5ASCN9APIK3CDCNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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