SCHEMBL31269236

SCHEMBL31269236

Cc1ccnc(Cn2c(-c3ccc(N4CCC4=O)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 3/20 0.34
▸ PAK1 Q13153 2/20 0.34
▸ KCNH2 Q12809 2/20 0.33
▸ SCN5A Q14524 1/20 0.33
▸ SCN9A Q15858 1/20 0.33
▸ CNR1 P21554 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31268976 0.95 PAK1 (0.39) PIK3CDPAK1KCNH2SCN5ASCN9A
SCHEMBL31268880 0.93 PIK3CD (0.32) PIK3CDPAK1KCNH2SCN5ASCN9A
SCHEMBL31269036 0.90 SLC6A2 (0.34) PIK3CDKCNH2SCN5ASCN9ACNR1
SCHEMBL31268826 0.90 PTGS2 (0.34) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269289 0.90 PIK3CD (0.34) PIK3CDKCNH2SCN5ASCN9ACNR1
SCHEMBL31269053 0.89 DGAT1 (0.35) PIK3CDKCNH2SCN5ASCN9ACNR1
SCHEMBL31269375 0.88 PIK3CD (0.37) PIK3CDKCNH2SCN5ASCN9ACNR1
SCHEMBL31269215 0.86 KCNH2 (0.34) PIK3CDKCNH2SCN5ASCN9ACNR1
SCHEMBL30983829 0.85 KCNH2 (0.34) PIK3CDKCNH2SCN5ASCN9ACNR1
SCHEMBL30983779 0.85 KCNH2 (0.36) PIK3CDKCNH2SCN5ASCN9ACNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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