SCHEMBL31268828

SCHEMBL31268828

Cc1cnc(Cn2c(-c3ccc(CC(N)=O)cc3Cl)nc3c(OC4(C)CC4)ncnc32)s1

nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 10/20 0.38
▸ DGAT1 O75907 1/20 0.34
▸ CNR1 P21554 2/20 0.31
▸ CNR2 P34972 2/20 0.31
▸ ALK Q9UM73 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31269353 0.90 DGAT1 (0.35) PIK3CDDGAT1CNR1CNR2
SCHEMBL31269311 0.90 PIK3CD (0.35) PIK3CDDGAT1CNR1CNR2
SCHEMBL31269283 0.89 PIK3CD (0.38) PIK3CDDGAT1CNR1CNR2
SCHEMBL31268988 0.88 PIK3CD (0.36) PIK3CDDGAT1CNR1CNR2
SCHEMBL31269203 0.88 PIK3CD (0.36) PIK3CDDGAT1CNR1CNR2
SCHEMBL31269290 0.88 PIK3CD (0.37) PIK3CDDGAT1CNR1CNR2
SCHEMBL31268788 0.87 PIK3CD (0.37) PIK3CDDGAT1CNR1CNR2
SCHEMBL31269497 0.87 PIK3CD (0.35) PIK3CDDGAT1CNR1CNR2
SCHEMBL31269255 0.86 PDE10A (0.38) PIK3CDDGAT1CNR1
SCHEMBL31269332 0.85 PIK3CD (0.36) PIK3CDDGAT1CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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