SCHEMBL31268890

SCHEMBL31268890

Cc1ccnc(Cn2c(-c3ccc(N4C[C@H]5CCN[C@H]5C4)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 4/20 0.34
▸ KCNH2 Q12809 1/20 0.32
▸ SCN5A Q14524 1/20 0.32
▸ SCN9A Q15858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31268997 0.87 PIK3CD (0.35) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269440 0.86 PIK3CD (0.34) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269090 0.85 HTR6 (0.35) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31268905 0.84 CHRNB2 (0.37) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269333 0.84 PIK3CD (0.37) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269320 0.83 HTR6 (0.34) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269124 0.83 CNR1 (0.33) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269231 0.82 PIK3CD (0.36) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269156 0.82 NTRK1 (0.33) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269289 0.81 PIK3CD (0.34) PIK3CDKCNH2SCN5ASCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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