SCHEMBL31268967

SCHEMBL31268967

Cc1ccnc(Cn2c(-c3ccc(CC(=O)NCCO)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.33

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 2/20 0.33
▸ ABL1 P00519 1/20 0.33
▸ EGFR P00533 1/20 0.33
▸ SRC P12931 1/20 0.33
▸ ABL2 P42684 1/20 0.33
▸ ALK Q9UM73 1/20 0.33
▸ WNT3A P56704 1/20 0.32
▸ MDM2 Q00987 1/20 0.31
▸ KCNH2 Q12809 1/20 0.31
▸ SCN5A Q14524 1/20 0.31
▸ SCN9A Q15858 1/20 0.31
▸ TDP1 Q9NUW8 1/20 0.31
▸ P2RX3 P56373 1/20 0.31
▸ CA2 P00918 1/20 0.30
▸ CYP3A4 P08684 1/20 0.30
▸ PDE4B Q07343 1/20 0.30
▸ MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31269254 0.96 PIK3CD (0.33) PIK3CDABL1EGFRSRCABL2
SCHEMBL31269356 0.93 PIK3CD (0.35) PIK3CDWNT3AKCNH2SCN5ASCN9A
SCHEMBL31269369 0.91 PIK3CD (0.35) PIK3CDWNT3AKCNH2SCN5ASCN9A
SCHEMBL31268746 0.91 PIK3CD (0.33) PIK3CDWNT3AKCNH2SCN5ASCN9A
SCHEMBL31269126 0.90 PIK3CD (0.34) PIK3CDWNT3AKCNH2SCN5ASCN9A
SCHEMBL31268860 0.90 TDP1 (0.33) PIK3CDWNT3AKCNH2SCN5ASCN9A
SCHEMBL31269338 0.90 PIK3CD (0.33) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269166 0.90 ALDH1A1 (0.40) PIK3CDP2RX3
SCHEMBL31269318 0.89 PIK3CD (0.38) PIK3CDWNT3AKCNH2SCN5ASCN9A
SCHEMBL31269404 0.89 KEAP1 (0.34) PIK3CDWNT3AKCNH2SCN5ASCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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