SCHEMBL31269316

SCHEMBL31269316

COc1cnnc(Cn2c(-c3ccc(CC(N)=O)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 2/20 0.35
▸ DGAT1 O75907 1/20 0.32
▸ CNR1 P21554 1/20 0.32
▸ PDE10A Q9Y233 1/20 0.30
▸ PLA2G2A P14555 1/20 0.30
▸ ALK Q9UM73 1/20 0.30
▸ SCD O00767 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31269172 0.92 PIK3CD (0.36) PIK3CDDGAT1CNR1
SCHEMBL31269240 0.91 PDE8A (0.35) PIK3CDDGAT1CNR1PDE10APLA2G2A
SCHEMBL31269255 0.90 PDE10A (0.38) PIK3CDDGAT1CNR1PDE10APLA2G2A
SCHEMBL31269283 0.86 PIK3CD (0.38) PIK3CDDGAT1CNR1PDE10A
SCHEMBL31268757 0.86 PLA2G2A (0.38) PLA2G2A
SCHEMBL31269332 0.86 PIK3CD (0.36) PIK3CDDGAT1CNR1
SCHEMBL30983368 0.85 PIK3CD (0.36) PIK3CDDGAT1CNR1PDE10A
SCHEMBL30983484 0.85 PIK3CD (0.36) PIK3CDDGAT1CNR1
SCHEMBL31269290 0.85 PIK3CD (0.37) PIK3CDDGAT1CNR1PDE10APLA2G2A
SCHEMBL31269129 0.85 PIK3CD (0.35) PIK3CDDGAT1CNR1PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
Send feedback