Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31270456 | 0.88 | WRN (0.53) | WRNMAPTKDRACHEMET | |
| SCHEMBL31047182 | 0.87 | WRN (0.50) | WRNMAPTACHENTRK1TP53 | |
| SCHEMBL31270593 | 0.86 | WRN (0.41) | WRNMAPTKDRACHEMET | |
| SCHEMBL31270642 | 0.86 | WRN (0.55) | WRNMAPTKDRACHESRPK1 | |
| Hydrochloric Acid SCHEMBL31270581 | 0.85 | WRN (0.51) | WRNMAPTKDRACHEMET | |
| SCHEMBL31270596 | 0.83 | WRN (0.58) | WRNMAPTKDRACHEKCNT1 | |
| SCHEMBL31270538 | 0.83 | WRN (0.50) | WRNMAPTACHEHDAC1MDM2 | |
| SCHEMBL31499786 | 0.82 | WRN (0.51) | WRNMAPTACHETP53MDM2 | |
| SCHEMBL31295761 | 0.80 | WRN (0.53) | WRNMAPTACHENTRK1AKR1B1 | |
| SCHEMBL30984140 | 0.80 | WRN (0.53) | WRNMAPTACHETP53AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024220887-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINONE WRN INHIBITORS | NIMBUS WADJET, INC. (US) | 2024-10-24 | — | — | WO | disclosed |