Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31270578 | 0.86 | WRN (0.48) | WRNKDRACHEMAPTKCNT1 | |
| SCHEMBL31047165 | 0.86 | ACHE (0.47) | WRNACHEMAPTTP53GAA | |
| Hydrochloric Acid SCHEMBL31270456 | 0.82 | WRN (0.53) | WRNKDRACHEMAPTKCNT1 | |
| SCHEMBL25035250 | 0.81 | ACHE (0.44) | WRNACHEMAPTTP53GAA | |
| SCHEMBL30037179 | 0.81 | ACHE (0.44) | WRNACHEMAPTTP53GAA | |
| SCHEMBL31499632 | 0.81 | WRN (0.45) | WRNACHEMAPTMDM2TP53 | |
| SCHEMBL30984234 | 0.79 | WRN (0.46) | WRNACHEMAPTTP53SMN1; SMN2 | |
| SCHEMBL31295862 | 0.79 | WRN (0.46) | WRNACHEMAPTGAANTRK1 | |
| SCHEMBL31295764 | 0.78 | WRN (0.49) | WRNACHEMAPTSMN1; SMN2TSHR | |
| SCHEMBL25036852 | 0.78 | WRN (0.61) | WRNACHEMAPTGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024220887-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINONE WRN INHIBITORS | NIMBUS WADJET, INC. (US) | 2024-10-24 | — | — | WO | disclosed |