Sugi Predict

Sugi Predict / Compounds / SCHEMBL31270807

SCHEMBL31270807

SCHEMBL31270807

CCCCc1nc2c(NC(C)(C)C)nc3cc(C)sc3c2n1CC1CCN(C(=O)OC(C)(C)C)CC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADORA2B P29275 1/20 0.40
▸ TLR8 Q9NR97 1/20 0.39
▸ TLR7 Q9NYK1 1/20 0.39
▸ GLS O94925 2/20 0.39
▸ RORC P51449 1/20 0.36
▸ KDM4E B2RXH2 2/20 0.35
▸ PKM P14618 1/20 0.35
▸ LMNA P02545 3/20 0.35
▸ THRB P10828 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ ALDH1A1 P00352 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ P2RX3 P56373 1/20 0.34
▸ TP53 P04637 2/20 0.34
▸ PIK3CA P42336 1/20 0.34
▸ PRKDC P78527 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25294832 1.00 ADORA2B (0.40) ADORA2BTLR8TLR7GLSRORC
SCHEMBL25296505 0.92 GLS (0.38) ADORA2BTLR7GLSRORCKDM4E
SCHEMBL31270541 0.90 GLS (0.37) GLSRORCLMNATHRBMAPT
SCHEMBL25256981 0.90 GLS (0.37) GLSRORCLMNATHRBMAPT
SCHEMBL31270667 0.89 GLS (0.36) ADORA2BGLSRORCKDM4EPKM
SCHEMBL31270666 0.89 TLR7 (0.38) TLR8TLR7GLSRORCLMNA
SCHEMBL25257815 0.89 TLR7 (0.38) TLR8TLR7GLSRORCLMNA
SCHEMBL25256345 0.89 GLS (0.36) ADORA2BGLSRORCKDM4EPKM
SCHEMBL25296097 0.88 TLR7 (0.40) TLR8TLR7GLSRORCLMNA
SCHEMBL31025940 0.88 TLR7 (0.40) TLR8TLR7GLSRORCLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260055119-A9 TRICYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN) 2026-02-26 — — US disclosed
US-20250257071-A9 TRICYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2025-08-14 — — US disclosed
US-20250002502-A1 TRICYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN) 2025-01-02 — — US disclosed
EP-4458830-A1 TRICYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) 2024-11-06 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257071-A9 TRICYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF CYP11B2, CYP11B1, CYP3A5 ADORA2B 1831/4885TLR8 3224/4885TLR7 2484/4885
US-20260055119-A9 TRICYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF CYP11B1, CYP11B2, CYP2D6 ADORA2B 2385/4885TLR8 3592/4885TLR7 2700/4885
US-20250002502-A1 TRICYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF CYP11B2, CYP11B1, CYP3A5 ADORA2B 1831/4885TLR8 3224/4885TLR7 2484/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.