Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31271175 | 0.85 | GPR119 (0.58) | GPR119RET | |
| SCHEMBL1011608 | 0.83 | ACACB (0.46) | GPR119NPSR1MAPTATMMEN1 | |
| SCHEMBL31270870 | 0.82 | GPR119 (0.56) | GPR119NPSR1MAPTMEN1ALDH1A1 | |
| SCHEMBL22777328 | 0.81 | GPR119 (0.59) | GPR119RET | |
| SCHEMBL31270777 | 0.80 | GPR119 (0.53) | GPR119JAK3RET | |
| SCHEMBL22776707 | 0.80 | GPR119 (0.51) | GPR119MEN1ALDH1A1GAAKMT2A | |
| SCHEMBL24962301 | 0.79 | GPR119 (0.57) | GPR119MAPTRET | |
| SCHEMBL12480371 | 0.79 | GPR119 (0.56) | GPR119MAPTATM | |
| SCHEMBL1012529 | 0.79 | ATM (0.44) | GPR119NPSR1MAPTATMMEN1 | |
| SCHEMBL22777069 | 0.79 | GPR119 (0.49) | GPR119MEN1ALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024249950-A1 | FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF MENIN | BIOMEA FUSION, INC. (US) | 2024-12-05 | — | — | WO | disclosed |