SCHEMBL31273232

SCHEMBL31273232

O=C(OCc1ccccc1)c1cccn1Br

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 4/20 0.54
KMT2A Q03164 2/20 0.54
SLC6A2 P23975 1/20 0.54
SLC6A3 Q01959 1/20 0.54
ALDH1A1 P00352 8/20 0.51
LMNA P02545 3/20 0.50
NPC1 O15118 3/20 0.49
RAB9A P51151 3/20 0.49
TSHR P16473 2/20 0.49
MAPK1 P28482 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
CYP3A4 P08684 1/20 0.47
MAPT P10636 3/20 0.44
MMP2 P08253 2/20 0.44
MMP9 P14780 2/20 0.44
MMP12 P39900 2/20 0.44
HPGD P15428 1/20 0.44
MMP1 P03956 1/20 0.44
KDM4E B2RXH2 1/20 0.43
MAOB P27338 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28311744 0.81 TDP1 (0.54) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL20201248 0.81 NPC1 (0.72) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL29020281 0.79 TDP1 (0.53) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL31500283 0.78 TDP1 (0.51) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL25893353 0.78 TDP1 (0.51) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL29020275 0.77 ALDH1A1 (0.53) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL6783056 0.76 TDP1 (0.49) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL29020239 0.76 RAB9A (0.51) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL28340801 0.76 TDP1 (0.49) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL29020291 0.76 ALDH1A1 (0.52) TDP1KMT2ASLC6A2SLC6A3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119100967-A 1-Aminosulfonyl-2-carboxypyrrole derivatives as metallo-beta-lactamase inhibitors 英菲克斯治疗有限公司 2024-12-10 CN disclosed