⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28397045 | 0.82 | — | — | |
| SCHEMBL5821217 | 0.82 | — | — | |
| SCHEMBL713294 | 0.82 | ALDH1A1 (0.46) | — | |
| SCHEMBL17821279 | 0.81 | DNM1 (0.42) | — | |
| SCHEMBL2888115 | 0.79 | ALDH1A1 (0.43) | — | |
| SCHEMBL24176856 | 0.77 | ALDH1A1 (0.42) | — | |
| SCHEMBL473168 | 0.77 | ALDH1A1 (0.42) | — | |
| SCHEMBL199628 | 0.77 | NFKB1 (0.44) | — | |
| SCHEMBL5928013 | 0.77 | — | — | |
| SCHEMBL17103725 | 0.75 | DNM1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2112154-B1 | Esters in position 20 of camptothecins | SIGMA TAU IND FARMACEUTI (IT) | 2013-07-24 | — | — | EP | disclosed |
| EP-1511752-B3 | CAMPTOTHECINS WITH A MODIFIED LACTONE RING | SIGMA TAU IND FARMACEUTI (IT) | 2010-03-10 | — | — | EP | disclosed |
| EP-2112154-A1 | Esters in position 20 of camptothecins | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2009-10-28 | — | — | EP | disclosed |
| EP-1509529-B1 | ESTERS IN POSITION 20 OF CAMPTOTHECINS | SIGMA TAU IND FARMACEUTI (IT) | 2009-08-12 | — | — | EP | disclosed |
| US-7498340-B2 | Esters in position 20 of camptothecins | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2009-03-03 | — | — | US | disclosed |
| US-7452900-B2 | Esters in position 20 of camptothecins | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-11-18 | — | — | US | disclosed |
| EP-1719775-B1 | Camptothecins with a modified lactone ring | SIGMA TAU IND FARMACEUTI (IT) | 2008-08-06 | — | — | EP | disclosed |
| US-7273873-B2 | Camptothecins with a modified lactone ring | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-09-25 | — | — | US | disclosed |
| US-20070213353-A1 | Esters in position 20 of camptothecins | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A., (IT) | 2007-09-13 | — | — | US | disclosed |
| EP-1511752-B8 | CAMPTOTHECINS WITH A MODIFIED LACTONE RING | SIGMA TAU IND FARMACEUTI (IT) | 2007-04-18 | — | — | EP | disclosed |
| EP-1719775-A1 | Camptothecins with a modified lactone ring | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2006-11-08 | — | — | EP | disclosed |
| EP-1511752-B1 | CAMPTOTHECINS WITH A MODIFIED LACTONE RING | SIGMA TAU IND FARMACEUTI (IT) | 2006-09-13 | — | — | EP | disclosed |
| US-20050256148-A1 | Esters in position 20 of camptothecins | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2005-11-17 | — | — | US | disclosed |
| US-20050154003-A1 | Camptothecins with a modified lactone ring | ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI (IT) | 2005-07-14 | — | — | US | disclosed |
| EP-1511752-A2 | CAMPTOTHECINS WITH A MODIFIED LACTONE RING | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003101995-A2 | CAMPTOTHECINS WITH A MODIFIED LACTONE RING | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2003-12-11 | — | — | WO | disclosed |