Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29378237 | 0.84 | CYP19A1 (0.46) | CYP19A1MC4RPTGDR2 | |
| SCHEMBL28263864 | 0.78 | CYP19A1 (0.68) | CYP19A1PTGDR2ADRA1ACCR1CCR2 | |
| SCHEMBL3117352 | 0.76 | CYP19A1 (0.42) | CYP19A1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL9579418 | 0.72 | HTR1A (0.41) | KDM4EALDH1A1PLA2G1BRAB9AATG4B | |
| SCHEMBL29378508 | 0.71 | P2RX7 (0.41) | MC4RRAB9A | |
| SCHEMBL9125316 | 0.70 | CYP19A1 (0.58) | CYP19A1PTGDR2CCR1CCR2RAB9A | |
| SCHEMBL11128645 | 0.70 | CYP19A1 (0.70) | CYP19A1CCR1CCR2RAB9ACCR4 | |
| SCHEMBL305310 | 0.70 | CYP19A1 (0.58) | CYP19A1PTGDR2ADRA1ACCR1CCR2 | |
| SCHEMBL1281769 | 0.70 | CYP19A1 (0.58) | CYP19A1PTGDR2KDM4E | |
| SCHEMBL12468869 | 0.70 | CYP19A1 (0.70) | CYP19A1CCR1CCR2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |