Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128665 | 0.87 | CARM1 (0.53) | CARM1PRMT6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3117849 | 0.86 | HTR1A (0.35) | CARM1PRMT6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10135160 | 0.85 | CARM1 (0.45) | CARM1PRMT6ALOX5APFEN1DCPS | |
| SCHEMBL3124811 | 0.81 | SLC6A2 (0.46) | CARM1PRMT6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3126134 | 0.78 | EPHX2 (0.33) | CARM1PRMT6FFAR4EPHX2 | |
| SCHEMBL3964707 | 0.76 | ATM (0.38) | ALOX5APFEN1CXCR2HTR2CHTR2B | |
| SCHEMBL3126431 | 0.76 | HTR1A (0.37) | CARM1PRMT6SLC6A4HTR2CSCN9A | |
| SCHEMBL3122107 | 0.75 | IDO1 (0.49) | CARM1PRMT6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3122115 | 0.74 | EPHX2 (0.45) | CARM1PRMT6DCPSTACR1EPHX2 | |
| SCHEMBL10302573 | 0.74 | HCRTR2 (0.41) | CARM1PRMT6ALOX5APFEN1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |