Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 2/20 | 0.53 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.53 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128158 | 0.87 | CARM1 (0.42) | CARM1PRMT6IDO1TACR1SLC6A2 | |
| SCHEMBL18615766 | 0.84 | CARM1 (0.57) | CARM1PRMT6IDO1TACR1HTR1A | |
| SCHEMBL3122107 | 0.81 | IDO1 (0.49) | CARM1PRMT6IDO1HTR1ASLC6A2 | |
| SCHEMBL3122115 | 0.80 | EPHX2 (0.45) | CARM1PRMT6TACR1 | |
| SCHEMBL19921471 | 0.80 | SLC6A2 (0.57) | CARM1PRMT6IDO1TACR1HTR1A | |
| SCHEMBL3117849 | 0.79 | HTR1A (0.35) | CARM1PRMT6HTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL1476112 | 0.79 | SLC6A2 (0.56) | CARM1PRMT6IDO1TACR1HTR1A | |
| SCHEMBL5523141 | 0.79 | CARM1 (0.52) | CARM1PRMT6IDO1TACR1HTR1A | |
| SCHEMBL3126431 | 0.78 | HTR1A (0.37) | CARM1PRMT6HTR1ASLC6A4SCN9A | |
| SCHEMBL7332875 | 0.78 | CARM1 (0.69) | CARM1PRMT6IDO1TACR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |