Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 5/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 5/20 | 0.38 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18616204 | 0.84 | EPHX2 (0.48) | EPHX2ADRA2AADRA2BADRA2CSIGMAR1 | |
| SCHEMBL13806992 | 0.83 | EPHX2 (0.47) | EPHX2ADRA2AADRA2BADRA2CSIGMAR1 | |
| SCHEMBL3128665 | 0.80 | CARM1 (0.53) | TACR1CARM1PRMT6 | |
| SCHEMBL1475230 | 0.80 | SLC6A4 (0.51) | EPHX2ADRA2AADRA2BADRA2CSIGMAR1 | |
| SCHEMBL2090766 | 0.78 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CDRD4TACR1 | |
| SCHEMBL3118843 | 0.76 | TACR1 (0.46) | TACR1CARM1PRMT6FFAR1 | |
| SCHEMBL11632158 | 0.76 | EPHX2 (0.41) | EPHX2ADRA2AADRA2BADRA2CSIGMAR1 | |
| SCHEMBL11561452 | 0.75 | DCPS (0.42) | EPHX2ADRA2AADRA2BADRA2CSIGMAR1 | |
| SCHEMBL2300380 | 0.75 | OPRM1 (0.51) | EPHX2SIGMAR1TMEM97CARM1PRMT6 | |
| SCHEMBL3128158 | 0.74 | CARM1 (0.42) | EPHX2TACR1CARM1PRMT6DCPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |