Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 8/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.52 |
| ▸ | PAK4 | O96013 | 4/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.46 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.46 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.46 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3118384 | 0.83 | CYP1A2 (0.46) | CHRNB2CHRNA4PAK4PAK1CYP1A2 | |
| SCHEMBL2299419 | 0.80 | CHRNB2 (0.47) | CHRNB2CHRNA4CYP1A2CYP3A4CYP3A5 | |
| SCHEMBL3124619 | 0.78 | MAP4K3 (0.46) | CHRNB2CHRNA4PAK1MAP4K3SCN9A | |
| SCHEMBL11938941 | 0.76 | CHRNB2 (0.44) | CHRNB2CHRNA4PAK4PAK1CYP1A2 | |
| SCHEMBL22392621 | 0.74 | CHRNB2 (0.55) | CHRNB2CHRNA4PAK4PAK1CYP1A2 | |
| SCHEMBL11932465 | 0.74 | CHRNB2 (0.42) | CHRNB2CHRNA4PAK4PAK1CYP1A2 | |
| SCHEMBL3246673 | 0.72 | RIPK1 (0.46) | CHRNB2CHRNA4CYP1A2CYP3A4CYP3A5 | |
| SCHEMBL9388340 | 0.72 | BRD4 (0.53) | CYP2A6 | |
| SCHEMBL3129380 | 0.70 | IRAK4 (0.46) | CHRNB2CHRNA4CYP1A2CYP3A4CYP3A5 | |
| SCHEMBL3247635 | 0.70 | PIK3CD (0.40) | CHRNB2CHRNA4CYP1A2CYP3A4CYP3A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |