Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | KHK | P50053 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17809808 | 0.90 | RIPK1 (0.52) | RIPK1ALKKCNH2RIPK3PIK3CD | |
| Ammonia Solution, Strong SCHEMBL28956716 | 0.89 | RIPK1 (0.51) | RIPK1ALKKCNH2RIPK3PIK3CD | |
| SCHEMBL3124619 | 0.84 | MAP4K3 (0.46) | KCNH2PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL2299419 | 0.84 | CHRNB2 (0.47) | ALKPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL3118417 | 0.84 | ALK (0.49) | RIPK1ALKKCNH2RIPK3PIK3CD | |
| SCHEMBL3126749 | 0.83 | ALK (0.59) | ALKKCNH2RIPK3CHRNB2CHRNA4 | |
| SCHEMBL3129380 | 0.82 | IRAK4 (0.46) | RIPK1ALKKCNH2RIPK3PIK3CD | |
| Hydrochloric Acid SCHEMBL20135201 | 0.82 | ALK (0.58) | ALKKCNH2RIPK3CHRNB2CHRNA4 | |
| SCHEMBL3113001 | 0.81 | MELK (0.47) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL3122986 | 0.81 | ALK (0.47) | ALKPIK3CDPIK3CAPIK3CBPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |