Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 8/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | PDE6C | P51160 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3130798 | 0.87 | PDE5A (0.44) | MTORTERTPDE5AKMT2AMEN1 | |
| SCHEMBL2809986 | 0.81 | PDE5A (0.43) | MTORTERTPDE5AKMT2AMEN1 | |
| SCHEMBL2880591 | 0.73 | ALDH1A1 (0.38) | MTORTERTPDE5AKMT2AMEN1 | |
| SCHEMBL7993573 | 0.71 | CYP1A2 (0.36) | — | |
| SCHEMBL4042877 | 0.71 | MTOR (0.39) | MTORTERTPDE5AKMT2AMEN1 | |
| SCHEMBL5435892 | 0.70 | PDE5A (0.40) | MTORTERTPDE5AKMT2AMEN1 | |
| SCHEMBL2857503 | 0.68 | PDE5A (0.38) | PDE5AKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL4037518 | 0.68 | PDE5A (0.36) | MTORTERTPDE5AKMT2AMEN1 | |
| SCHEMBL3127667 | 0.68 | PDE5A (0.61) | MTORTERTPDE5AKMT2AMEN1 | |
| SCHEMBL4037512 | 0.67 | PDE5A (0.38) | MTORTERTPDE5AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168967-A1 | INTERMEDIATES FOR PREPARATION OF AN INHIBITOR OF PHOSPHODIESTERASE TYPE 5 | Galenicum Health, S.l. (ES) | 2010-03-31 | — | — | EP | disclosed |