Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31080 | 0.81 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL31079 | 0.81 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL17787544 | 0.81 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL30498 | 0.77 | PDE10A (0.32) | CRHR1 | |
| SCHEMBL31284 | 0.76 | — | — | |
| SCHEMBL31282 | 0.76 | — | — | |
| SCHEMBL596486 | 0.75 | ALDH1A1 (0.37) | CRHR1 | |
| SCHEMBL7881389 | 0.70 | CRHR1 (0.30) | CRHR1 | |
| SCHEMBL30183 | 0.69 | CRHR1 (0.33) | CRHR1 | |
| SCHEMBL10280617 | 0.69 | CRHR1 (0.33) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608668-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | Merck Sharp & Dohme Corp. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |