Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TARBP2 | Q15633 | 3/20 | 0.50 |
| ▸ | RXRA | P19793 | 2/20 | 0.48 |
| ▸ | RXRB | P28702 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487202 | 0.91 | IKBKB (0.56) | IKBKBHPGDNPC1RAB9APOLB | |
| SCHEMBL16072947 | 0.90 | IKBKB (0.64) | IKBKBHPGDNPC1RAB9ANFKB1 | |
| SCHEMBL3124515 | 0.88 | IKBKB (0.65) | IKBKBHPGDNPC1RAB9ANFKB1 | |
| SCHEMBL7701897 | 0.87 | KDM4E (0.55) | HPGDNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL7695337 | 0.85 | IKBKB (0.55) | IKBKBHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7701209 | 0.84 | NPC1 (0.51) | IKBKBHPGDNPC1RAB9ANFKB1 | |
| SCHEMBL7699801 | 0.84 | ALDH1A1 (0.51) | IKBKBHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3127884 | 0.84 | IKBKB (0.56) | IKBKBHPGDNPC1RAB9APOLB | |
| SCHEMBL7693588 | 0.82 | KDM4E (0.65) | HPGDNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL1166974 | 0.81 | IKBKB (0.44) | IKBKBHPGDNPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170849-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | Sareum Limited (GB) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008139161-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | SAREUM LIMITED (GB) | 2008-11-20 | — | — | WO | disclosed |