Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 3/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 4/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31292354 | 0.87 | PLCG1 (0.39) | PLCG1BRS3RXRAGRIN1GRIN2B | |
| SCHEMBL31292402 | 0.83 | SHMT1 (0.33) | RXRAGRIN1GRIN2BHCRTR1HCRTR2 | |
| SCHEMBL24759679 | 0.80 | PLCG1 (0.42) | PLCG1BRS3MEN1KMT2ACYP2C19 | |
| SCHEMBL31292610 | 0.80 | PLCG1 (0.42) | PLCG1MEN1OPRM1OPRD1KMT2A | |
| SCHEMBL24759676 | 0.78 | PLCG1 (0.41) | PLCG1BRS3MEN1KMT2ACYP2C19 | |
| SCHEMBL24759681 | 0.78 | MTNR1A (0.42) | PLCG1BRS3CYP2C19HCRTR1HCRTR2 | |
| SCHEMBL12341062 | 0.77 | CCR1 (0.39) | RXRAGRIN1GRIN2BHCRTR1HCRTR2 | |
| SCHEMBL31292498 | 0.76 | PLCG1 (0.40) | PLCG1BRS3KMT2ACYP2C19CNR2 | |
| SCHEMBL23355549 | 0.75 | HCRTR1 (0.40) | RXRAGRIN1GRIN2BCYP2C19HCRTR1 | |
| SCHEMBL31292380 | 0.73 | KDM5A (0.35) | RXRAGRIN1GRIN2BHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250340528-A1 | TARGETED PROTEIN DEGRADATION | MONTE ROSA THERAPEUTICS AG (CH) | 2025-11-06 | — | — | US | disclosed |
| US-12459920-B2 | Targeted protein degradation | MONTE ROSA THERAPEUTICS AG (CH) | 2025-11-04 | — | — | US | disclosed |
| US-20250243180-A1 | TARGETED PROTEIN DEGRADATION | MONTE ROSA THERAPEUTICS AG (CH) | 2025-07-31 | — | — | US | disclosed |
| WO-2025024521-A1 | SUBSTITUTED PIPERIDINEDIONES FOR TARGETED PROTEIN DEGRADATION | MONTE ROSA THERAPEUTICS, INC. (US) | 2025-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250243180-A1 | TARGETED PROTEIN DEGRADATION | NEK7, NEK1, RIPK1 | PLCG1 4629/4885BRS3 4802/4885RXRA 3387/4885 |
| US-12459920-B2 | Targeted protein degradation | NEK7, NEK1, RIPK1 | PLCG1 4630/4885BRS3 4803/4885RXRA 3396/4885 |
| US-20250340528-A1 | TARGETED PROTEIN DEGRADATION | NEK7, NEK1, RIPK1 | PLCG1 4629/4885BRS3 4802/4885RXRA 3387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.