Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1992628 | 1.00 | NPC1 (0.33) | NPC1RAB9APPARACYP1A2CYP3A4 | |
| SCHEMBL6468604 | 0.83 | RAB9A (0.41) | NPC1RAB9APPARACYP1A2CYP3A4 | |
| SCHEMBL12073942 | 0.82 | RAB9A (0.47) | NPC1RAB9APPARACYP1A2CYP3A4 | |
| SCHEMBL3126260 | 0.80 | GPR119 (0.37) | NPC1RAB9APPARACYP1A2CYP3A4 | |
| SCHEMBL6468594 | 0.79 | RAB9A (0.40) | NPC1RAB9APPARACYP1A2CYP3A4 | |
| SCHEMBL1580908 | 0.79 | CHRM2 (0.40) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL661609 | 0.74 | TLR9 (0.42) | PLAT | |
| SCHEMBL13522010 | 0.73 | EPHA2 (0.41) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL9724642 | 0.73 | TLR9 (0.42) | PLAT | |
| SCHEMBL13179115 | 0.72 | RAB9A (0.42) | NPC1RAB9APPARACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |