Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | AGXT | P21549 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.40 |
| ▸ | NAAA | Q02083 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3129985 | 0.84 | HTR6 (0.46) | GRM2IDO1AGXTHTR1ANAAA | |
| SCHEMBL6927532 | 0.81 | CARM1 (0.49) | GRM2IDO1AGXTHTR1ACARM1 | |
| SCHEMBL10819401 | 0.78 | CARM1 (0.50) | GRM2IDO1AGXTHTR1ACARM1 | |
| SCHEMBL13003371 | 0.75 | GRM2 (0.42) | GRM2IDO1AGXTHTR1ACARM1 | |
| SCHEMBL3122107 | 0.75 | IDO1 (0.49) | GRM2IDO1AGXTHTR1ACARM1 | |
| SCHEMBL6926360 | 0.75 | SLC6A4 (0.51) | GRM2IDO1AGXTHTR1ANAAA | |
| SCHEMBL3117849 | 0.73 | HTR1A (0.35) | HTR1ACARM1PRMT6NAAAKDM4E | |
| SCHEMBL27246487 | 0.71 | IDO1 (0.51) | IDO1AGXTHTR1ANAAAKDM4E | |
| SCHEMBL13060199 | 0.71 | DPP4 (0.52) | SMN1; SMN2MGLL | |
| SCHEMBL31381199 | 0.70 | ALDH1A1 (0.45) | GRM2IDO1AGXTHTR1ANAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |