Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 6/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7062835 | 0.85 | DRD4 (0.58) | DRD4TMEM97SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL8449011 | 0.83 | DRD4 (0.56) | DRD4TMEM97SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL3118256 | 0.82 | SLC6A2 (0.62) | DRD4TMEM97SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL507357 | 0.81 | DRD4 (0.48) | DRD4TMEM97SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL24493163 | 0.78 | HRH3 (0.61) | DRD4TMEM97SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL29119715 | 0.78 | NAAA (0.59) | DRD4TMEM97SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL3113350 | 0.78 | CARM1 (0.51) | SLC6A2SLC6A4SLC6A3MAOBNPC1 | |
| SCHEMBL3121141 | 0.78 | CARM1 (0.51) | DRD4SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3118428 | 0.78 | NAAA (0.48) | DRD4TMEM97SIGMAR1TACR1NAAA | |
| SCHEMBL2300380 | 0.78 | OPRM1 (0.51) | TMEM97SIGMAR1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |