Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31304569 | 1.00 | PRMT5 (0.53) | PRMT5USP30TRPV1JAK2JAK1 | |
| SCHEMBL31304277 | 0.87 | GPR119 (0.47) | USP30 | |
| SCHEMBL31383657 | 0.80 | TRPV3 (0.53) | PRMT5USP30JAK2JAK1PARP1 | |
| SCHEMBL26772556 | 0.79 | PRMT5 (0.49) | PRMT5USP30TRPV1JAK2JAK1 | |
| SCHEMBL31304198 | 0.77 | CHEK2 (0.47) | PRMT5USP30PARP1 | |
| SCHEMBL17962250 | 0.77 | JAK3 (0.49) | PRMT5USP30TRPV1JAK2JAK1 | |
| SCHEMBL20281881 | 0.77 | PRMT5 (0.45) | PRMT5USP30TRPV1JAK2JAK1 | |
| SCHEMBL28834341 | 0.77 | USP30 (0.53) | PRMT5USP30JAK2JAK1 | |
| SCHEMBL31304186 | 0.77 | USP30 (0.52) | USP30PARP1HDAC4HDAC6TRPV3 | |
| SCHEMBL28834338 | 0.77 | USP30 (0.53) | PRMT5USP30JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724443-A1 | PYRAZOLO-PYRIMIDINONE COMPOUNDS FOR USE IN METHODS OF INHIBITING WEE1 A KINASE | Acrivon Therapeutics, Inc. (US) | 2026-04-15 | — | — | EP | disclosed |
| WO-2024254490-A1 | PYRAZOLO-PYRIMIDINONE COMPOUNDS FOR USE IN METHODS OF INHIBITING WEE1 A KINASE | ACRIVON THERAPEUTICS, INC. (US) | 2024-12-12 | — | — | WO | disclosed |