SCHEMBL31306012

SCHEMBL31306012

CC(=O)c1nc(Cl)ccc1F

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.37
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
PTGS2 P35354 2/20 0.37
KMT2A Q03164 3/20 0.35
GAA P10253 2/20 0.35
MEN1 O00255 1/20 0.35
KCNQ3 O43525 2/20 0.33
KCNQ2 O43526 2/20 0.33
KCNE1 P15382 2/20 0.33
KCNQ1 P51787 2/20 0.33
ABL1 P00519 1/20 0.33
RAB9A P51151 1/20 0.33
ADORA2A P29274 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
KEAP1 Q14145 1/20 0.32
NFE2L2 Q16236 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16166183 1.00 ALDH1A1 (0.37) ALDH1A1LMNAMAPTPTGS2KMT2A
SCHEMBL29202700 0.82 ALDH1A1 (0.38) ALDH1A1LMNAKMT2AGAAMEN1
SCHEMBL1760173 0.82 KEAP1 (0.41) ALDH1A1MAPTKMT2AGAAMEN1
SCHEMBL16176006 0.80 CASP3 (0.33)
SCHEMBL15651124 0.80 IKBKB (0.40) ALDH1A1LMNAKMT2AGAAMEN1
SCHEMBL24859645 0.79 TSHR (0.41) ALDH1A1MAPTKMT2AGAAMEN1
SCHEMBL30054378 0.79 NPSR1 (0.47) ALDH1A1LMNAMAPTKMT2AGAA
SCHEMBL2894142 0.79 NPSR1 (0.47) ALDH1A1LMNAMAPTKMT2AGAA
SCHEMBL18412839 0.79 GAA (0.42) ALDH1A1LMNAMAPTKMT2AGAA
SCHEMBL18498680 0.79 CTSA (0.40) PTGS2KMT2AGAAMEN1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119173511-A Benzotriazole compounds 第一三共株式会社 2024-12-20 CN disclosed