Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 9/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136054 | 0.92 | SSTR5 (0.41) | SSTR5SSTR1KCNH2CHRM2CHRM3 | |
| SCHEMBL3086973 | 0.89 | SSTR5 (0.53) | SSTR5HRH1SSTR1KCNH2KDM4E | |
| SCHEMBL3132193 | 0.89 | SSTR5 (0.39) | SSTR5KCNH2KDM4EALDH1A1CHRM2 | |
| SCHEMBL3136029 | 0.89 | SSTR5 (0.44) | SSTR5KCNH2 | |
| SCHEMBL3138725 | 0.88 | MEN1 (0.39) | SSTR5KCNH2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3142488 | 0.86 | SSTR5 (0.43) | SSTR5KCNH2KDM4EALDH1A1TDP1 | |
| SCHEMBL3137220 | 0.86 | SSTR5 (0.38) | SSTR5HRH1KCNH2CHRM2CHRM3 | |
| SCHEMBL3138164 | 0.84 | SSTR5 (0.56) | SSTR5KCNH2 | |
| SCHEMBL3138780 | 0.82 | PDE4B (0.41) | SSTR5KDM4EALDH1A1SMN1; SMN2CHRM2 | |
| SCHEMBL3138335 | 0.81 | ALDH1A1 (0.39) | SSTR5ALDH1A1CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142528-B1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | HOFFMANN LA ROCHE (CH) | 2010-07-07 | — | — | EP | claimed |