Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | LTK | P29376 | 1/20 | 0.54 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CDK7 | P50613 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19437101 | 1.00 | METAP2 (0.59) | METAP2L3MBTL1CHEK1NTRK1FYN | |
| SCHEMBL9996355 | 0.74 | METAP2 (1.00) | METAP2L3MBTL1KDM4ELMNAMAPT | |
| SCHEMBL11955286 | 0.74 | L3MBTL1 (0.66) | METAP2L3MBTL1MMP9MMP2KDM4E | |
| SCHEMBL10414290 | 0.74 | CDK1 (0.67) | METAP2L3MBTL1MMP9MMP2KDM4E | |
| SCHEMBL10415547 | 0.74 | MAPT (0.66) | METAP2L3MBTL1MMP9MMP2KDM4E | |
| SCHEMBL4665070 | 0.74 | KDM1A (0.55) | L3MBTL1KDM4ELMNAMAPTTDP1 | |
| SCHEMBL31452761 | 0.73 | METAP2 (0.97) | METAP2L3MBTL1KDM4ELMNAMAPT | |
| Hydrochloric Acid SCHEMBL11663296 | 0.72 | MAPT (0.64) | METAP2L3MBTL1MMP9MMP2KDM4E | |
| SCHEMBL31307151 | 0.72 | KDM4E (0.62) | METAP2L3MBTL1MMP9MMP2KDM4E | |
| SCHEMBL19437094 | 0.72 | KDM4E (0.62) | METAP2L3MBTL1MMP9MMP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440070-B1 | MDR-REVERSING 8-HYDROXY-QUINOLINE DERIVATIVES | MTA TERMESZETTUDOMANYI KUTATOKOEZPONT (HU) | 2024-10-30 | — | — | EP | claimed |