Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26275394 | 0.78 | KDM4E (0.44) | HTTALDH1A1KDM4EPKMOPRL1 | |
| SCHEMBL11684887 | 0.77 | HTT (0.64) | KDM1AHTTGLANPSR1ALDH1A1 | |
| SCHEMBL24093077 | 0.77 | HTT (0.64) | KDM1AHTTGLANPSR1ALDH1A1 | |
| SCHEMBL11682509 | 0.77 | HTT (0.64) | KDM1AHTTGLANPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11684770 | 0.76 | HTT (0.67) | KDM1AHTTGLANPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11687432 | 0.76 | HTT (0.67) | KDM1AHTTGLANPSR1ALDH1A1 | |
| SCHEMBL8265284 | 0.75 | HTT (0.61) | KDM1AHTTGLANPSR1ALDH1A1 | |
| SCHEMBL31307153 | 0.74 | METAP2 (0.59) | HTTNPSR1ALDH1A1KDM4EKMT2A | |
| SCHEMBL19437101 | 0.74 | METAP2 (0.59) | HTTNPSR1ALDH1A1KDM4EKMT2A | |
| SCHEMBL18677308 | 0.74 | LMNA (0.41) | HTTALDH1A1KDM4EPKMOPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924561-A2 | 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | Eli Lilly & Company (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007028083-A2 | 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-03-08 | — | — | WO | disclosed |