Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 8/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452841 | 0.75 | KDM4E (0.56) | GRM5RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL18542720 | 0.75 | CDK2 (0.46) | GRM5MAPT | |
| SCHEMBL1908379 | 0.71 | DHODH (0.56) | GRM5ATMRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL355054 | 0.71 | ALDH1A1 (0.50) | RAB9ANPC1SMN1; SMN2PKMMAPT | |
| SCHEMBL1104644 | 0.71 | KMT2A (0.53) | RAB9ANPC1SMN1; SMN2PKMMAPT | |
| SCHEMBL17827959 | 0.70 | GRM5 (0.41) | GRM5RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL15174346 | 0.70 | GRM5 (0.39) | GRM5RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL3960441 | 0.69 | GRM5 (0.68) | GRM5SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL16230541 | 0.69 | GRM5 (0.46) | GRM5RAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL19552354 | 0.69 | ALDH1A1 (0.42) | GRM5RAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |