Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453338 | 0.82 | RAB9A (0.59) | KDM4ELMNASMN1; SMN2CNR2RAB9A | |
| SCHEMBL22452840 | 0.76 | MEN1 (0.58) | LMNARAB9ANPC1MAPK1ALDH1A1 | |
| SCHEMBL31308905 | 0.75 | GRM5 (0.45) | KDM4ELMNASMN1; SMN2RAB9ANPC1 | |
| Methyl Nicotinate SCHEMBL5258435 | 0.75 | ALDH1A1 (0.59) | KDM4ELMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL7281512 | 0.75 | DHODH (0.71) | SMN1; SMN2RAB9ANPC1MAPK1ALDH1A1 | |
| SCHEMBL10642215 | 0.74 | KDM4E (0.56) | KDM4ESMN1; SMN2CNR2RAB9ANPC1 | |
| SCHEMBL1373504 | 0.74 | RAB9A (0.48) | KDM4ELMNASMN1; SMN2CNR2RAB9A | |
| SCHEMBL20546008 | 0.74 | KDM4E (0.58) | KDM4ELMNACNR2RAB9ANPC1 | |
| SCHEMBL13641200 | 0.73 | KDM4E (0.48) | KDM4ELMNACNR2RAB9ANPC1 | |
| SCHEMBL22445163 | 0.72 | RAB9A (0.60) | KDM4ELMNASMN1; SMN2CNR2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |