Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11698430 | 0.79 | ALDH1A1 (0.63) | PLK1DRD2LMNATP53MAPT | |
| SCHEMBL19086968 | 0.78 | GAA (0.47) | LMNAMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL19086962 | 0.78 | ALDH1A1 (0.60) | LMNATP53MAPTALDH1A1HTT | |
| SCHEMBL15555952 | 0.77 | JAK2 (0.48) | PLK1DRD2LMNATP53MAPT | |
| SCHEMBL3487668 | 0.76 | MAPK1 (0.56) | LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL31316712 | 0.75 | KCNH2 (0.44) | DRD2LMNAJAK2KCNH2NR1H2 | |
| SCHEMBL9292891 | 0.75 | HTT (0.54) | LMNATERTNAMPTALDH1A1CA1 | |
| SCHEMBL31316873 | 0.72 | KCNH2 (0.46) | DRD2LMNAJAK2KCNH2NR1H2 | |
| SCHEMBL19086932 | 0.72 | MAPT (0.45) | PLK1DRD2LMNAMAPTALDH1A1 | |
| SCHEMBL12395128 | 0.72 | SMN1; SMN2 (0.53) | LMNAMAPTTERTNAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743453-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015178-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |