Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 11/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 11/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31316712 | 0.77 | KCNH2 (0.44) | KCNH2NR1H2NR1H3CYP2C9CYP2D6 | |
| SCHEMBL23320351 | 0.76 | MAPT (0.46) | KCNH2NR1H2NR1H3CYP2C9CYP2D6 | |
| SCHEMBL11337983 | 0.74 | ADORA1 (0.54) | LMNA | |
| SCHEMBL11698430 | 0.72 | ALDH1A1 (0.63) | NR1H2NR1H3CYP2C9CYP3A4DRD2 | |
| SCHEMBL31316813 | 0.72 | PLK1 (0.41) | KCNH2NR1H2NR1H3DRD2LMNA | |
| SCHEMBL15870658 | 0.71 | KMT2A (0.46) | KCNH2NR1H2NR1H3CYP2C9CYP2D6 | |
| SCHEMBL23320393 | 0.70 | MEN1 (0.40) | KCNH2NR1H2NR1H3CYP2C9CYP2D6 | |
| SCHEMBL27932944 | 0.70 | KAT6A (0.51) | KCNH2DRD2LMNA | |
| SCHEMBL15555952 | 0.70 | JAK2 (0.48) | NR1H2NR1H3DRD2LMNAGRM5 | |
| SCHEMBL23320573 | 0.68 | NAMPT (0.48) | KCNH2NR1H2NR1H3CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743453-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015178-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |