Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3125839 | 0.90 | MAPK1 (0.52) | ALDH1A1HSD17B10ALOX15USP2LMNA | |
| SCHEMBL3135556 | 0.90 | ALOX15 (0.46) | ALDH1A1HSD17B10ALOX15USP2LMNA | |
| SCHEMBL3137243 | 0.89 | ALOX15 (0.46) | ALDH1A1HSD17B10ALOX15USP2LMNA | |
| SCHEMBL3098832 | 0.89 | HCAR3 (0.52) | ALDH1A1HSD17B10ALOX15NPC1RAB9A | |
| SCHEMBL3130756 | 0.88 | ALOX15 (0.44) | ALDH1A1HSD17B10ALOX15USP2LMNA | |
| SCHEMBL3133939 | 0.87 | ALOX15 (0.45) | ALDH1A1HSD17B10ALOX15USP2LMNA | |
| SCHEMBL3133522 | 0.87 | ALOX15 (0.47) | ALDH1A1HSD17B10ALOX15USP2LMNA | |
| SCHEMBL3137489 | 0.87 | ALDH1A1 (0.46) | ALDH1A1HSD17B10ALOX15USP2LMNA | |
| SCHEMBL3138171 | 0.87 | ALDH1A1 (0.51) | ALDH1A1HSD17B10ALOX15USP2LMNA | |
| SCHEMBL3138758 | 0.87 | SSTR5 (0.49) | ALDH1A1HSD17B10ALOX15USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142528-B1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | HOFFMANN LA ROCHE (CH) | 2010-07-07 | — | — | EP | claimed |