Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHR | P34981 | 6/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14185753 | 1.00 | TRHR (0.68) | TRHR | |
| SCHEMBL14185750 | 0.91 | TRHR (0.57) | TRHR | |
| SCHEMBL14185774 | 0.90 | TRHR (0.55) | TRHR | |
| SCHEMBL31332262 | 0.90 | TRHR (0.66) | TRHR | |
| SCHEMBL14185746 | 0.88 | TRHR (0.55) | TRHR | |
| SCHEMBL14185751 | 0.88 | TRHR (0.57) | TRHR | |
| SCHEMBL11182741 | 0.88 | TRHR (0.66) | TRHR | |
| SCHEMBL11331704 | 0.88 | TRHR (0.66) | TRHR | |
| SCHEMBL1371608 | 0.88 | TRHR (0.66) | TRHR | |
| SCHEMBL11327973 | 0.88 | TRHR (0.66) | TRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794182-B1 | COMPOUNDS THAT MODULATE TRH ACTIONS AND INHIBIT THE TRH-DEGRADING ENZYME | TRINITY COLLEGE DUBLIN (IE) | 2015-06-03 | — | — | EP | disclosed |
| EP-1261624-B1 | TRH-LIKE PEPTIDE DERIVATIVES AS INHIBITORS OF THE TRH-DEGRADING ECTOENZYME | TRINITY COLLEGE DUBLIN (IE) | 2010-07-07 | — | — | EP | disclosed |
| US-7378397-B2 | TRH-degrading ectoenzyme inhibitors | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2008-05-27 | — | — | US | disclosed |
| US-20060293247-A1 | TRH-like peptide derivatives as inhibitors of the TRH-degrading ectoenzyme | The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen | 2006-12-28 | — | — | US | disclosed |
| US-20030166944-A1 | TRH-like peptide derivatives as inhibitors of the TRH-degrading ectoenzyme | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF TH HOLY | 2003-09-04 | — | — | US | disclosed |
| EP-1261624-A1 | TRH-LIKE PEPTIDE DERIVATIVES AS INHIBITORS OF THE TRH-DEGRADING ECTOENZYME | The Provost, Fellows and Scholars of the College of the Holy and Undivide Trinity of Queen Elisabeth near Dublin (IE) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001060843-A1 | TRH-LIKE PEPTIDE DERIVATIVES AS INHIBITORS OF THE TRH-DEGRADING ECTOENZYME | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2001-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166944-A1 | TRH-like peptide derivatives as inhibitors of the TRH-degrading ectoenzyme | TRHDE, TRHR, TSHR | TRHR 2/4885 |
| US-20060293247-A1 | TRH-like peptide derivatives as inhibitors of the TRH-degrading ectoenzyme | TRHR, TRHDE, TSHR | TRHR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.