Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KLK7 | P49862 | 2/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29130086 | 0.90 | ABCB1 (0.57) | ABCB1MAPTKLK7KLK5ITGB3 | |
| SCHEMBL29617084 | 0.86 | ABCB1 (0.53) | ABCB1MAPTKLK7KLK5ITGB3 | |
| SCHEMBL25371879 | 0.82 | ABCB1 (0.51) | ABCB1MAPTKLK7KLK5ITGB3 | |
| SCHEMBL21248918 | 0.81 | ABCB1 (0.53) | ABCB1MAPTKLK7KLK5ITGB3 | |
| SCHEMBL30803525 | 0.80 | HTT (0.48) | ABCB1MAPTKLK7KLK5ITGB3 | |
| SCHEMBL30803543 | 0.80 | HTT (0.48) | ABCB1MAPTKLK7KLK5ITGB3 | |
| SCHEMBL30829529 | 0.79 | ABCB1 (0.49) | ABCB1MAPTKLK7KLK5ITGB3 | |
| SCHEMBL29991950 | 0.79 | HTT (0.51) | ABCB1MAPTHTTKEAP1NFE2L2 | |
| SCHEMBL25233266 | 0.79 | HSD11B1 (0.50) | ABCB1DPP7L3MBTL1KMT2ADPP4 | |
| SCHEMBL30397918 | 0.79 | HSD11B1 (0.50) | ABCB1DPP7L3MBTL1KMT2ADPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735452-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS PROTEIN | Merck Patent GmbH (DE) | 2026-05-06 | — | — | EP | disclosed |
| WO-2025006753-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS PROTEIN | MERCK PATENT GMBH (DE) | 2025-01-02 | — | — | WO | disclosed |