SCHEMBL31327140

SCHEMBL31327140

Cc1nn(CC2CCC2)c(Cl)c1C=O

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.38
MAPT P10636 3/20 0.38
MEN1 O00255 1/20 0.38
RAB9A P51151 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
POLB P06746 1/20 0.36
P2RX7 Q99572 1/20 0.34
CRHR1 P34998 3/20 0.33
ALDH1A1 P00352 2/20 0.33
LMNA P02545 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
P2RY14 Q15391 1/20 0.33
NPBWR1 P48145 1/20 0.33
NR3C1 P04150 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HTT P42858 1/20 0.32
PDE5A O76074 1/20 0.31
HTR2C P28335 1/20 0.31
SLC6A4 P31645 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL308090 0.76 SMN1; SMN2 (0.36) KMT2AMAPTMEN1RAB9AALDH1A1
SCHEMBL24014301 0.76 MAPT (0.36) KMT2AMAPTMEN1RAB9ANPSR1
SCHEMBL29952457 0.73 ADORA2A (0.40) KMT2AMAPTMEN1RAB9ANPSR1
SCHEMBL29955476 0.72 RAB9A (0.42) KMT2AMEN1RAB9APOLBP2RX7
SCHEMBL31327106 0.72 SMN1; SMN2 (0.34) KMT2AP2RX7ALDH1A1LMNAL3MBTL1
SCHEMBL29956676 0.71 SMN1; SMN2 (0.36) KMT2AMAPTMEN1RAB9AALDH1A1
SCHEMBL11904367 0.71 ALDH1A1 (0.50) KMT2AMEN1RAB9AALDH1A1LMNA
SCHEMBL854856 0.71 ALDH1A1 (0.37) KMT2AMAPTMEN1NPSR1P2RX7
SCHEMBL31327029 0.70 SMN1; SMN2 (0.35) KMT2AMAPTMEN1NPSR1ALDH1A1
SCHEMBL853448 0.70 ALDH1A1 (0.39) KMT2AMEN1POLBALDH1A1NR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250066383-A1 PDE 7 MODULATOR COMPOUNDS OMEROS CORPORATION 2025-02-27 US disclosed
WO-2025042956-A1 PDE 7 MODULATOR COMPOUNDS OMEROS CORPORATION (US) 2025-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250066383-A1 PDE 7 MODULATOR COMPOUNDS PDE7A, PDE3A, PDE3B KMT2A 1896/4885MAPT 810/4885MEN1 2648/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.