Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11921143 | 0.81 | ALDH1A1 (0.45) | ALDH1A1GAALMNAKMT2AMEN1 | |
| SCHEMBL308090 | 0.79 | SMN1; SMN2 (0.36) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL29952457 | 0.76 | ADORA2A (0.40) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL31327106 | 0.75 | SMN1; SMN2 (0.34) | ALDH1A1LMNAL3MBTL1KMT2AKDM4E | |
| SCHEMBL29955476 | 0.75 | RAB9A (0.42) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL964648 | 0.74 | KMT2A (0.60) | ALDH1A1GAALMNAL3MBTL1KMT2A | |
| SCHEMBL29956676 | 0.73 | SMN1; SMN2 (0.36) | ALDH1A1GAAL3MBTL1KMT2AMEN1 | |
| SCHEMBL2563126 | 0.72 | SMN1; SMN2 (0.35) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL16681803 | 0.72 | SMN1; SMN2 (0.37) | ALDH1A1GAAL3MBTL1KMT2AMEN1 | |
| SCHEMBL29953949 | 0.72 | ADRA1A (0.36) | ALDH1A1L3MBTL1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2487178-A1 | PYRAZOLOTHIAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2012-08-15 | — | — | EP | disclosed |