Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thioguanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 1.00 |
| ▸ | HBB | P68871 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | MAPK3 | P27361 | 1/20 | 1.00 |
| ▸ | XDH | P47989 | 1/20 | 1.00 |
| ▸ | PAX8 | Q06710 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | PNP | P00491 | 1/20 | 0.44 |
| ▸ | POLA1 | P09884 | 1/20 | 0.42 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thioguanine SCHEMBL3702 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HPGDTP53PTGS1HBB | |
| Thioguanine SCHEMBL28134237 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HPGDTP53PTGS1HBB | |
| Thioguanine SCHEMBL28189107 | 0.98 | ALDH1A1 (0.96) | ALDH1A1HPGDTP53PTGS1HBB | |
| Thioguanine SCHEMBL27871418 | 0.98 | ALDH1A1 (0.96) | ALDH1A1HPGDTP53PTGS1HBB | |
| Thioguanine SCHEMBL28105522 | 0.98 | ALDH1A1 (0.96) | ALDH1A1HPGDTP53PTGS1HBB | |
| Thioguanine SCHEMBL27820845 | 0.93 | ALDH1A1 (0.87) | ALDH1A1HPGDTP53PTGS1HBB | |
| Thioguanine SCHEMBL28286968 | 0.92 | ALDH1A1 (0.84) | ALDH1A1HPGDTP53PTGS1HBB | |
| Thioguanine SCHEMBL27688865 | 0.89 | ALDH1A1 (0.79) | ALDH1A1HPGDTP53PTGS1HBB | |
| Thioguanine SCHEMBL16243773 | 0.89 | ALDH1A1 (0.79) | ALDH1A1HPGDTP53PTGS1HBB | |
| Thioguanine SCHEMBL28160995 | 0.87 | ALDH1A1 (0.77) | ALDH1A1HPGDTP53PTGS1HBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12622914-B2 | Pharmaceutical rectal suppository compositions of 6-thioguanine, methods of treatment and/or methods of manufacturing | DOUGLAS PHARMACEUTICALS LTD. (NZ) | 2026-05-12 | — | — | US | disclosed |
| US-20250064816-A1 | PHARMACEUTICAL RECTAL SUPPOSITORY COMPOSITIONS OF 6-THIOGUANINE, METHODS OF TREATMENT AND/OR METHODS OF MANUFACTURING | DOUGLAS PHARMACEUTICALS LTD. (NZ) | 2025-02-27 | — | — | US | disclosed |
| WO-2025042298-A1 | PHARMACEUTICAL RECTAL SUPPOSITORY COMPOSITIONS OF 6-THIOGUANINE, METHODS OF TREATMENT AND/OR METHODS OF MANUFACTURING | DOUGLAS PHARMACEUTICALS LIMITED (NZ) | 2025-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12622914-B2 | Pharmaceutical rectal suppository compositions of 6-thioguanine, methods of treatment and/or methods of manufacturing | TPMT, IL6, MALT1 | ALDH1A1 1436/4885HPGD 36/4885TP53 1963/4885 |
| US-20250064816-A1 | PHARMACEUTICAL RECTAL SUPPOSITORY COMPOSITIONS OF 6-THIOGUANINE, METHODS OF TREATMENT AND/OR METHODS OF MANUFACTURING | TPMT, TREH, GMPS | ALDH1A1 549/4885HPGD 79/4885TP53 3742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.