Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21981041 | 1.00 | HDAC4 (0.40) | HDAC4HDAC7HDAC5DPP4DPP7 | |
| SCHEMBL21981039 | 1.00 | HDAC4 (0.40) | HDAC4HDAC7HDAC5DPP4DPP7 | |
| SCHEMBL21981040 | 1.00 | HDAC4 (0.40) | HDAC4HDAC7HDAC5DPP4DPP7 | |
| SCHEMBL29332823 | 0.88 | HDAC4 (0.38) | HDAC4HDAC7HDAC5CNR2MTOR | |
| SCHEMBL17841446 | 0.87 | GABRB1 (0.37) | CTSLCTSSCTSKMEN1LMNA | |
| SCHEMBL17841444 | 0.87 | GABRB1 (0.37) | CTSLCTSSCTSKMEN1LMNA | |
| SCHEMBL17841447 | 0.87 | GABRB1 (0.37) | CTSLCTSSCTSKMEN1LMNA | |
| SCHEMBL23112571 | 0.84 | CTSL (0.37) | HDAC4HDAC7HDAC5DPP4DPP7 | |
| SCHEMBL23112568 | 0.84 | CTSL (0.37) | HDAC4HDAC7HDAC5DPP4DPP7 | |
| SCHEMBL23112570 | 0.84 | CTSL (0.37) | HDAC4HDAC7HDAC5DPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4736855-A2 | TETRAHYDROPYRAN (THP)-SUBSTITUTED BICYCLIC-PYRIMIDINEDIONE COMPOUNDS | MyoKardia, Inc. (US) | 2026-05-06 | — | — | EP | disclosed |
| CN-119977963-A | Tetrahydropyrane (THP) -substituted bicyclic pyrimidinedione compounds | 迈奥卡迪亚公司 | 2025-05-13 | — | — | CN | disclosed |
| CN-113056465-B | Tetrahydropyrane (THP) -substituted bicyclic pyrimidinedione compounds | 迈奥卡迪亚公司 | 2025-01-28 | — | — | CN | disclosed |