Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.39 |
| ▸ | TRPC6 | Q9Y210 | 6/20 | 0.39 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23089250 | 1.00 | CHRNB2 (0.44) | CHRNB2CHRNA4GABRPGABRDGABRA1 | |
| SCHEMBL30630187 | 0.91 | CHRNB2 (0.47) | CHRNB2CHRNA4GABRPGABRDGABRA1 | |
| SCHEMBL27676284 | 0.83 | TRPC6 (0.43) | CHRNB2CHRNA4GABRPGABRDGABRA1 | |
| SCHEMBL25191769 | 0.83 | TRPC6 (0.43) | CHRNB2CHRNA4GABRPGABRDGABRA1 | |
| SCHEMBL29736294 | 0.81 | HDAC1 (0.52) | HSD11B1 | |
| SCHEMBL12425406 | 0.81 | RET (0.40) | CHRNB2CHRNA4TRPC6 | |
| SCHEMBL2305956 | 0.81 | HDAC1 (0.52) | HSD11B1 | |
| SCHEMBL29644776 | 0.79 | NOTUM (0.45) | CHRNB2CHRNA4GABRPGABRDGABRA1 | |
| SCHEMBL23089380 | 0.79 | MAPT (0.59) | CHRNB2CHRNA4SMN1; SMN2CHRNB4CHRNA3 | |
| SCHEMBL1394162 | 0.78 | CHRNB2 (0.42) | CHRNB2CHRNA4GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119874700-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-114945366-B | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2025-01-07 | — | — | CN | disclosed |