Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | F12 | P00748 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5370648 | 0.80 | ALDH1A1 (0.52) | MAPTALDH1A1HSP90AA1RECQLRAB9A | |
| SCHEMBL8421057 | 0.77 | MAPT (0.45) | MAPTALDH1A1HSP90AA1RECQLKMT2A | |
| SCHEMBL4047461 | 0.73 | ALDH1A1 (0.40) | MAPTALDH1A1HSP90AA1RECQLRAB9A | |
| SCHEMBL437911 | 0.71 | F2 (0.48) | MAPTALDH1A1HSP90AA1RECQLAOC3 | |
| SCHEMBL312846 | 0.71 | HSD11B1 (0.52) | MAPTALDH1A1RECQLRAB9AKMT2A | |
| SCHEMBL429907 | 0.71 | ALDH1A1 (0.67) | MAPTALDH1A1HSP90AA1AOC3RAB9A | |
| SCHEMBL21386356 | 0.71 | MEN1 (0.47) | MAPTALDH1A1HSP90AA1AOC3RAB9A | |
| Iodide SCHEMBL10428908 | 0.70 | F2 (0.46) | MAPTALDH1A1HSP90AA1RECQLAOC3 | |
| SCHEMBL3126210 | 0.70 | ALDH1A1 (0.50) | MAPTALDH1A1RAB9AKMT2ANPC1 | |
| SCHEMBL21690488 | 0.68 | MAPT (0.40) | MAPTALDH1A1HSP90AA1RECQLAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8907131-B2 | Compounds for treating proliferative disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140031429-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | KOYA KEIZO (US) | 2014-01-30 | — | — | US | disclosed |
| US-8455686-B2 | Compounds for treating proliferative disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20120095103-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-04-19 | — | — | US | disclosed |
| US-8093425-B2 | Compounds for treating proliferative disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2012-01-10 | — | — | US | disclosed |
| US-20090023736-A1 | Compounds for treating proliferative disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2009-01-22 | — | — | US | disclosed |
| WO-2008136976-A2 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023736-A1 | Compounds for treating proliferative disorders | HSP90AB1, HSF1, HSP90B1 | MAPT 1817/4885ALDH1A1 690/4885HSP90AA1 6/4885 |
| US-20120095103-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | HSP90AB1, HSF1, HSP90B1 | MAPT 1817/4885ALDH1A1 690/4885HSP90AA1 6/4885 |
| US-20140031429-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | HSP90AB1, HSF1, HSP90B1 | MAPT 1817/4885ALDH1A1 690/4885HSP90AA1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.