SCHEMBL31334190

SCHEMBL31334190

CC(C)(C)OC(=O)N1CCC(C(=O)N2CCC[C@H](Nc3ncc(Cl)c(-c4cccc(-c5ccccc5)c4)n3)C2)CC1

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
USP30 Q70CQ3 4/20 0.52
MAPK1 P28482 4/20 0.49
MAPK10 P53779 6/20 0.48
MAPK8 P45983 6/20 0.48
MAPK9 P45984 6/20 0.48
JUN P05412 5/20 0.48
CDK2 P24941 4/20 0.48
MAPK3 P27361 2/20 0.44
CKS1B P61024 1/20 0.44
SKP1 P63208 1/20 0.44
SKP2 Q13309 1/20 0.44
CCNK O75909 1/20 0.43
CDK12 Q9NYV4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334669 0.94 USP30 (0.59) USP30MAPK1MAPK10MAPK8MAPK9
SCHEMBL31333309 0.94 USP30 (0.59) USP30MAPK1MAPK10MAPK8MAPK9
SCHEMBL31334616 0.91 MAPK8 (0.51) USP30MAPK1MAPK10MAPK8MAPK9
SCHEMBL31333217 0.89 MAPK8 (0.54) USP30MAPK1MAPK10MAPK8MAPK9
SCHEMBL31333916 0.88 MAPK1 (0.53) USP30MAPK1MAPK10MAPK8MAPK9
SCHEMBL31333392 0.85 MAPK10 (0.51) MAPK1MAPK10MAPK8MAPK9JUN
SCHEMBL31335014 0.85 CCNT1 (0.49) MAPK1MAPK10MAPK8MAPK9JUN
SCHEMBL31333428 0.85 MAPK8 (0.47) USP30MAPK1MAPK10MAPK8MAPK9
SCHEMBL31334934 0.83 MAPK3 (0.58) MAPK1MAPK10MAPK8MAPK9JUN
SCHEMBL31333325 0.83 MAPK3 (0.58) MAPK1MAPK10MAPK8MAPK9JUN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed