SCHEMBL31333428

SCHEMBL31333428

CC(C)(C)OC(=O)N1CCC2(CCC(C(=O)N3CCC(Nc4ncc(Cl)c(-c5cccc(-c6ccccc6)c5)n4)CC3)CC2)CC1

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 7/20 0.47
MAPK9 P45984 7/20 0.47
MAPK10 P53779 5/20 0.47
MAPK1 P28482 6/20 0.44
CCNT1 O60563 1/20 0.44
USP30 Q70CQ3 2/20 0.44
JUN P05412 6/20 0.42
CDK2 P24941 6/20 0.42
IDH1 O75874 1/20 0.42
IDH2 P48735 1/20 0.42
CNR1 P21554 1/20 0.41
CNR2 P34972 1/20 0.41
FNTA P49354 1/20 0.41
FNTB P49356 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334616 0.93 MAPK8 (0.51) MAPK8MAPK9MAPK10MAPK1CCNT1
SCHEMBL31333217 0.91 MAPK8 (0.54) MAPK8MAPK9MAPK10MAPK1CCNT1
SCHEMBL31334708 0.89 MAPK1 (0.51) MAPK8MAPK9MAPK10MAPK1JUN
SCHEMBL31334405 0.88 CDK2 (0.50) MAPK8MAPK9MAPK10MAPK1JUN
SCHEMBL31335014 0.87 CCNT1 (0.49) MAPK8MAPK9MAPK10MAPK1CCNT1
SCHEMBL31334130 0.85 MAPK1 (0.47) MAPK8MAPK9MAPK10MAPK1JUN
SCHEMBL31334190 0.85 USP30 (0.52) MAPK8MAPK9MAPK10MAPK1USP30
SCHEMBL31334054 0.84 CCNT1 (0.52) MAPK8MAPK9MAPK10MAPK1CCNT1
SCHEMBL31333767 0.84 MAPK8 (0.50) MAPK8MAPK9MAPK10MAPK1CCNT1
SCHEMBL31334146 0.83 MAPK8 (0.49) MAPK8MAPK9MAPK10MAPK1CCNT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed