SCHEMBL31334357

SCHEMBL31334357

N[C@H]1CC[C@H](Nc2ncc(Cl)c(-c3cccc(-n4ccccc4=O)c3)n2)CC1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SYK P43405 2/20 0.46
CCNT1 O60563 4/20 0.45
CDK7 P50613 9/20 0.44
CDK9 P50750 8/20 0.44
CSNK1A1 P48729 1/20 0.44
CSNK1D P48730 1/20 0.44
CSNK1E P49674 1/20 0.44
CCNH P51946 1/20 0.44
MAPK8 P45983 1/20 0.43
MAPK10 P53779 1/20 0.43
PCSK9 Q8NBP7 2/20 0.42
MAPK1 P28482 2/20 0.42
FLT3 P36888 1/20 0.42
ADORA1 P30542 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333852 0.89 SYK (0.46) SYKCCNT1CDK7CDK9CSNK1A1
SCHEMBL31334573 0.89 MAPK1 (0.49) SYKCCNT1CDK7CDK9CCNH
SCHEMBL31335065 0.87 MAPK1 (0.45) SYKPCSK9MAPK1
SCHEMBL31333721 0.87 MAPK1 (0.45) SYKPCSK9MAPK1
SCHEMBL31334939 0.86 MAPK1 (0.44) SYKMAPK8MAPK10PCSK9MAPK1
SCHEMBL31334050 0.86 MAPK1 (0.44) SYKMAPK8MAPK10PCSK9MAPK1
SCHEMBL31333940 0.85 MAPK1 (0.48) SYKMAPK1
SCHEMBL31334093 0.83 CCNT1 (0.53) CCNT1CDK7CDK9CSNK1A1CSNK1D
SCHEMBL31334905 0.83 CCNT1 (0.53) CCNT1CDK7CDK9CSNK1A1CSNK1D
SCHEMBL31334729 0.83 CCNT1 (0.53) CCNT1CDK7CDK9CSNK1A1CSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed