SCHEMBL31333940

SCHEMBL31333940

O=C(CBr)N[C@H]1CC[C@H](Nc2ncc(Cl)c(-c3cccc(-n4ccccc4=O)c3)n2)CC1

nearest known ligand 0.48

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 18/20 0.48
GRIN2B Q13224 1/20 0.43
SYK P43405 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333756 0.90 SYK (0.42) MAPK1GRIN2BSYK
SCHEMBL31333549 0.90 SYK (0.42) MAPK1GRIN2BSYK
SCHEMBL31335065 0.89 MAPK1 (0.45) MAPK1SYK
SCHEMBL31333721 0.89 MAPK1 (0.45) MAPK1SYK
SCHEMBL31334250 0.88 MAPK1 (0.49) MAPK1
SCHEMBL31334357 0.85 SYK (0.46) MAPK1SYK
SCHEMBL31334050 0.84 MAPK1 (0.44) MAPK1SYK
SCHEMBL31334939 0.84 MAPK1 (0.44) MAPK1SYK
SCHEMBL31334573 0.83 MAPK1 (0.49) MAPK1SYK
SCHEMBL31334426 0.81 MAPK1 (0.49) MAPK1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed