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SCHEMBL31334402

SCHEMBL31334402

Cn1c(=O)n(C2CCC(=O)NC2=O)c2ccc(C3CCN(CC4CCN(CC(=O)N5CCC(Nc6ncc(F)c(-c7cccc(-c8ccccc8)c7)n6)CC5)CC4)CC3)cc21

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 5/20 0.37
▸ CRBN Q96SW2 9/20 0.36
▸ DDB1 Q16531 3/20 0.36
▸ BTK Q06187 6/20 0.36
▸ IKZF2 Q9UKS7 1/20 0.35
▸ IRAK1 P51617 1/20 0.34
▸ IRAK4 Q9NWZ3 1/20 0.34
▸ IRAK3 Q9Y616 1/20 0.34
▸ IKZF1 Q13422 2/20 0.34
▸ ENPP2 Q13822 1/20 0.34
▸ CDK4 P11802 1/20 0.33
▸ CDK6 Q00534 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334762 0.97 MAPK1 (0.36) MAPK1CRBNDDB1BTKIKZF2
SCHEMBL31333626 0.93 MAPK1 (0.44) MAPK1
SCHEMBL31334994 0.93 CRBN (0.35) MAPK1CRBNDDB1BTKIKZF2
SCHEMBL31334361 0.91 MAPK1 (0.41) MAPK1
SCHEMBL31333715 0.87 MAPK1 (0.44) MAPK1
SCHEMBL31334680 0.87 MAPK1 (0.41) MAPK1CRBN
SCHEMBL31334665 0.87 MAPK1 (0.44) MAPK1
SCHEMBL31333932 0.86 CRBN (0.36) MAPK1CRBNDDB1BTKIKZF2
SCHEMBL31334436 0.84 MAPK1 (0.39) MAPK1CRBN
SCHEMBL31334794 0.83 MAPK1 (0.41) MAPK1CRBNDDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 — — EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 — — WO disclosed